Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice
نویسندگان
چکیده
منابع مشابه
Histidine Decarboxylase Deficiency Prevents Autoimmune Diabetes in NOD Mice
Recent evidence has highlighted the role of histamine in inflammation. Since this monoamine has also been strongly implicated in the pathogenesis of type-1 diabetes, we assessed its effect in the nonobese diabetic (NOD) mouse model. To this end, we used mice (inactivated) knocked out for the gene encoding histidine decarboxylase, the unique histamine-forming enzyme, backcrossed on a NOD genetic...
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Previous work has revealed that Cx36, the sole connexin expressed in the insulin-producing beta cells, enhances the secretion of insulin, and promotes the resistance of beta cells against pro-inflammatory cytokines. In parallel, the anti-diabetic sulphonylurea glibenclamide was shown to promote the assembly and function of Cx36 channels. Here, we assessed whether glibenclamide could protect the...
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OBJECTIVE Insulitis is an important pathological feature of autoimmune diabetes; however, mechanisms governing the recruitment of diabetogenic T-cells into pancreatic islets are poorly understood. Here, we determined the importance of leukocyte integrins beta(2)(Itgb2) and alphaL (ItgaL) in developing insulitis and frank diabetes. RESEARCH DESIGN AND METHODS Gene-targeted mutations of either ...
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*Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-ku, Seoul 135-710, Korea; †Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, TMP532, P.O. Box 208020, New Haven, CT 06520-8020; and §Department of Pharmacology, School of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jo...
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Advanced glycation end products (AGEs) are implicated in beta-cell oxidant stress. Diet-derived AGE (dAGE) are shown to contribute to end-organ toxicity attributed to diabetes. To assess the role of dAGE on type 1 diabetes, NOD mice were exposed to a high-AGE diet (H-AGE) and to a nutritionally similar diet with approximate fivefold-lower levels of N(epsilon)-carboxymethyllysine (CML) and methy...
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ژورنال
عنوان ژورنال: Journal of Diabetes Research
سال: 2015
ISSN: 2314-6745,2314-6753
DOI: 10.1155/2015/965056